There appears to be a strange conflict with substance painter and chitubox.
Does chitubox do something to win10 explorer / shell? Some known issues with substance painter is custom windows shells.
Everything is updated to the latest versions including chitubox, nvidia drivers, win10 etc.
I can only use substance painter if I uninstall chitubox.
Chitubox also freezes for a second when moving the cursor between the different UI regions inside chitubox.
System specs
i9-9900k
32gb Gskill 3600
Nvidia 2070 Super
Maximus XI Hero
Kingston 2tb A2000 SSD's
Win10
Attached peripherals
Wacom Tablet
Mouse & KB